Maternal circulating miRNAs that predict infant FASD outcomes influence placental maturation.

ABSTRACT: Prenatal alcohol exposure (PAE), like other pregnancy complications, can result in placental insufficiency and fetal growth restriction, although the linking causal mechanisms are unclear. We previously identified 11 gestationally elevated maternal circulating miRNAs (_HEamiRNAs) that predicted infant growth deficits following PAE. Here, we investigated whether these _HEamiRNAs contribute to the pathology of PAE, by inhibiting trophoblast epithelial-mesenchymal transition (EMT), a pathway critical for placental development. We now report for the first time that PAE inhibits expression of placental pro-EMT pathway members in both rodents and primates, and that _HEamiRNAs collectively, but not individually, mediate placental EMT inhibition. _HEamiRNAs

SUBMITTER: Tseng AM 

PROVIDER: S-EPMC6399548 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature