Urine proteome changes associated with autonomic regulation of heart rate in cosmonauts.

ABSTRACT:

Background

The strategy of adaptation of the human body in microgravity is largely associated with the plasticity of cardiovascular system regulatory mechanisms. During long-term space flights the changes in the stroke volume of the heart are observed, the heart rate decreases, the phase structure of cardiac cycle is readjusted The purpose of this work was to clarify urine proteome changes associated with the initial condition of the heart rate autonomic regulation mechanisms in cosmonauts who have participated in long space missions. Urine proteome of each cosmonaut was analyzed before and after space flight, depending on the initial parameters characterizing the regulatory mechanisms of the cardiovascular system.

Results

The proteins cadherin-13, mucin-1, alpha-1 of collag

SUBMITTER: Pastushkova LH 

PROVIDER: S-EPMC6399814 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature