Enriched gestation activates the IGF pathway to evoke embryo-adult benefits to prevent Alzheimer's disease.

ABSTRACT:

Background

Building brain reserves before dementia onset could represent a promising strategy to prevent Alzheimer's disease (AD), while how to initiate early cognitive stimulation is unclear. Given that the immature brain is more sensitive to environmental stimuli and that brain dynamics decrease with ageing, we reasoned that it would be effective to initiate cognitive stimulation against AD as early as the fetal period.

Methods

After conception, maternal AD transgenic mice (3 × Tg AD) were exposed to gestational environment enrichment (GEE) until the day of delivery. The cognitive capacity of the offspring was assessed by the Morris water maze and contextual fear-conditioning tests when the offspring were raised in a standard environment to 7 months of age. Western blottin

SUBMITTER: Liu E 

PROVIDER: S-EPMC6399936 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature