Personalized virtual-heart technology for guiding the ablation of infarct-related ventricular tachycardia.

ABSTRACT: Ventricular tachycardia (VT), which can lead to sudden cardiac death, occurs frequently in patients with myocardial infarction. Catheter-based radiofrequency ablation of cardiac tissue has achieved only modest efficacy, owing to the inaccurate identification of ablation targets by current electrical mapping techniques, which can lead to extensive lesions and to a prolonged, poorly tolerated procedure. Here we show that personalized virtual-heart technology based on cardiac imaging and computational modelling can identify optimal infarct-related VT ablation targets in retrospective animal (5 swine) and human studies (21 patients) and in a prospective feasibility study (5 patients). We first assessed in retrospective studies (one of which included a proportion of clinical images with artifac

SUBMITTER: Prakosa A 

PROVIDER: S-EPMC6400313 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature