Antidepressants are modifiers of lipid bilayer properties.

ABSTRACT: The two major classes of antidepressants, tricyclic antidepressants (TCAs) and selective serotonin reuptake inhibitors (SSRIs), inhibit neurotransmitter reuptake at synapses. They also have off-target effects on proteins other than neurotransmitter transporters, which may contribute to both desired changes in brain function and the development of side effects. Many proteins modulated by antidepressants are bilayer spanning and coupled to the bilayer through hydrophobic interactions such that the conformational changes underlying their function will perturb the surrounding lipid bilayer, with an energetic cost (ΔG _def) that varies with changes in bilayer properties. Here, we test whether changes in ΔG _def caused by amphiphilic antidepressants partitioning

SUBMITTER: Kapoor R 

PROVIDER: S-EPMC6400527 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature