Gα_s-coupled receptor signaling and sleep regulate integrin activation of human antigen-specific T cells.

ABSTRACT: Efficient T cell responses require the firm adhesion of T cells to their targets, e.g., virus-infected cells, which depends on T cell receptor (TCR)-mediated activation of β₂-integrins. Gα_s-coupled receptor agonists are known to have immunosuppressive effects, but their impact on TCR-mediated integrin activation is unknown. Using multimers of peptide major histocompatibility complex molecules (pMHC) and of ICAM-1-the ligand of β₂-integrins-we show that the Gα_s-coupled receptor agonists isoproterenol, epinephrine, norepinephrine, prostaglandin (PG) E₂, PGD₂, and adenosine strongly inhibit integrin activation on human CMV- and EBV-specific CD8⁺ T cells in a dose-dependent manner. In contrast, sleep, a natural condit

SUBMITTER: Dimitrov S 

PROVIDER: S-EPMC6400544 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature