Smooth Muscle Contact Drives Endothelial Regeneration by BMPR2-Notch1-Mediated Metabolic and Epigenetic Changes.

ABSTRACT:

Rationale

Maintaining endothelial cells (EC) as a monolayer in the vessel wall depends on their metabolic state and gene expression profile, features influenced by contact with neighboring cells such as pericytes and smooth muscle cells (SMC). Failure to regenerate a normal EC monolayer in response to injury can result in occlusive neointima formation in diseases such as atherosclerosis and pulmonary arterial hypertension.

Objective

We investigated the nature and functional importance of contact-dependent communication between SMC and EC to maintain EC integrity.

Methods and results

We found that in SMC and EC contact cocultures, BMPR2 (bone morphogenetic protein receptor 2) is required by both cell types to produce collagen IV to activate ILK (integrin-linked kinase)

SUBMITTER: Miyagawa K 

PROVIDER: S-EPMC6400637 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature