Phenotypic and transcriptomic characterization of canine myeloid-derived suppressor cells.

ABSTRACT: Myeloid-derived suppressor cells (MDSCs) are key players in immune evasion, tumor progression and metastasis. MDSCs accumulate under various pathological states and fall into two functionally and phenotypically distinct subsets that have been identified in humans and mice: polymorphonuclear (PMN)-MDSCs and monocytic (M)-MDSCs. As dogs are an excellent model for human tumor development and progression, we set out to identify PMN-MDSCs and M-MDSCs in clinical canine oncology patients. Canine hypodense MHC class II^-CD5^-CD21^-CD11b⁺ cells can be subdivided into polymorphonuclear (CADO48A⁺CD14^-) and monocytic (CADO48A^-CD14⁺) MDSC subsets. The transcriptomic signatures of PMN-MDSCs and M-MDSCs are distinct, an

SUBMITTER: Goulart MR 

PROVIDER: S-EPMC6400936 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature