Trends in Pediatric Central Nervous System Tumor Incidence in the United States, 1998-2013.

ABSTRACT:

Background

Brain and other central nervous system (CNS) cancers are the leading cause of U.S. pediatric cancer mortality. Incidence trends can provide etiologic insight. We report trends in incidence rates of pediatric malignant CNS cancers and pilocytic astrocytoma (nonmalignant but historically registered) in the United States.

Methods

Age-standardized incidence rates and annual percent changes (APC) in rates during 1998 to 2013 were calculated for children aged 0 to 19, stratified by subtype, age, sex, and for gliomas, histology and location. We estimated the absolute change in number of cases diagnosed U.S.-wide during 2013 compared with the expected number of cases had 1998 rates remained stable.

Results

Rates of all pediatric malignant CNS cancer combined (n<

SUBMITTER: Withrow DR 

PROVIDER: S-EPMC6401271 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature