The Role of Early Bioelectric Signals in the Regeneration of Planarian Anterior/Posterior Polarity.

ABSTRACT: Axial patterning during planarian regeneration relies on a transcriptional circuit that confers distinct positional information on the two ends of an amputated fragment. The earliest known elements of this system begin demarcating differences between anterior and posterior wounds by 6 h postamputation. However, it is still unknown what upstream events break the axial symmetry, allowing a mutual repressor system to establish invariant, distinct biochemical states at the anterior and posterior ends. Here, we show that bioelectric signaling at 3 h is crucial for the formation of proper anterior-posterior polarity in planaria. Briefly manipulating the endogenous bioelectric state by depolarizing the injured tissue during the first 3 h of regeneration alters gene expression by 6 h postamputatio

SUBMITTER: Durant F 

PROVIDER: S-EPMC6401388 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature