β-Cyclodextrin⁻Hyaluronic Acid Polymer Functionalized Magnetic Graphene Oxide Nanocomposites for Targeted Photo-Chemotherapy of Tumor Cells.

ABSTRACT: A multifunctional targeted drug delivery platform (CDHA⁻MGO) has been successfully constructed by grafting β-cyclodextrin⁻hyaluronic acid polymers (CDHA) to Fe₃O₄⁻graphene oxide (MGO). The obtained CDHA⁻MGO nanocomposite has good water-dispersibility, easy magnetic separation, high near-infrared (NIR) photothermal heating, and excellent biocompatibility. The β-cyclodextrin-hyaluronic acid polymers efficaciously enhance the doxorubicin (DOX) loading amount up to 485.43 mg·g-1. Meanwhile, the Fe₃O₄⁻graphene oxide provides a facile photothermal response mechanism to handle the NIR-triggered release of DOX in weak acidic solvent environments. Significantly, the DOX-loaded nanocomposite (DOX@CDHA⁻MGO) has displayed CD44 receptor-mediated active targeting recognition and chemo-photothermal syner

SUBMITTER: Liang W 

PROVIDER: S-EPMC6401939 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature