Association of genetically predicted testosterone with thromboembolism, heart failure, and myocardial infarction: mendelian randomisation study in UK Biobank.

ABSTRACT:

Objective

To determine whether endogenous testosterone has a causal role in thromboembolism, heart failure, and myocardial infarction.

Design

Two sample mendelian randomisation study using genetic variants as instrumental variables, randomly allocated at conception, to infer causality as additional randomised evidence.

Setting

Reduction by Dutasteride of Prostate Cancer Events (REDUCE) randomised controlled trial, UK Biobank, and CARDIoGRAMplusC4D 1000 Genomes based genome wide association study.

Participants

3225 men of European ancestry aged 50-75 in REDUCE; 392 038 white British men and women aged 40-69 from the UK Biobank; and 171 875 participants of about 77% European descent, from CARDIoGRAMplusC4D 1000 Genomes based study for validation.

Main outcome

SUBMITTER: Luo S 

PROVIDER: S-EPMC6402044 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature