Effects of formulation composition on the characteristics of mucoadhesive films prepared by hot-melt extrusion technology.

ABSTRACT:

Objectives

To investigate the effects of formulation composition on the physico-chemical and drug release properties of mucoadhesive buccal films prepared by melt extrusion technology, using a response surface methodology.

Methods

Salbutamol sulphate, an antiasthmatic drug was used for this study. Klucel hydroxypropylcellulose (HPC) EF (film-forming polymer), Benecel hydroxypropylmethylcellulose (HPMC) K-15M (drug release retardant) and polyethylene glycol (PEG) 4500 (plasticiser) were the three independent factors utilised for the study. The responses were fitted to a full quadratic model and P-values for each of the factors were used to determine their significance on the film characteristics.

Key findings

Films were successfully extruded using the corotating twin-s

SUBMITTER: Bhagurkar AM 

PROVIDER: S-EPMC6402047 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature