Importance of finding the bona fide target of the Fanconi anemia pathway.
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ABSTRACT:
SUBMITTER: Sakai W
PROVIDER: S-EPMC6402094 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Publications
Importance of finding the bona fide target of the Fanconi anemia pathway.
Sakai Wataru W Sugasawa Kaoru K
Genes and environment : the official journal of the Japanese Environmental Mutagen Society 20190306
Fanconi anemia (FA) is a rare genetic disease characterized by the deficiency of the cellular response and repair pathway for DNA interstrand crosslink (ICL) damage. Although recent studies have revealed the detailed molecular functions of FA proteins encoded by 22 genes, the mechanism of occurrence of endogenous ICLs in the human body remains poorly understood. In this short review, we summarize the potential endogenous sources of ICLs counteracted by FA proteins, and provide perspectives on th ...[more]
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