Serum Thyroglobulin: Preoperative Levels and Factors Affecting Postoperative Optimal Timing following Total Thyroidectomy.

ABSTRACT:

Objective

We evaluated if preoperative TG levels affected postoperative levels and if other factors may influence the optimal time to check postoperative TG.

Methods

This is a prospective, observational pilot study. We approved and enrolled 50 subjects ≥ 19 years scheduled for total thyroidectomy and measured serum TG, thyroglobulin antibody (TG ab), and TSH preoperatively and post thyroidectomy at 7-14 days, 4 and 6 weeks, and 3 months in subjects with benign pathology, with additional 6- and 12-month measurements in subjects with thyroid cancer.

Results

Preoperative TG was significantly higher in the benign (median 167.5 ng/mL vs 30.8 ng/mL) than in the malignant (p = 0.0006) group. In the benign group, 76.5% (13/17) of subjects had an undetectable TG < 0.2 n

SUBMITTER: Patel A 

PROVIDER: S-EPMC6402205 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature