Is orthostatic hypotension related to falling? A meta-analysis of individual patient data of prospective observational studies.

ABSTRACT:

Background

orthostatic hypotension (OH) is one out of many risk factors believed to contribute to an increased fall risk in elderly subjects but it is unclear whether an independent association between OH and falling exists.

Objectives

to perform an individual patient data (IPD) meta-analysis of prospective observational studies investigating the relationship between OH and falling.

Design

MEDLINE, EMBASE, the Cochrane Library and the abstracts of annual meetings of selected hypertension societies were searched. Both one-stage (analysing all IPD from all studies simultaneously) and two-stage (analysing IPD per study, and then pooling the results) methods were used, and both logistic and cox regression analyses were performed. The study protocol was published on PROSPE

SUBMITTER: Hartog LC 

PROVIDER: S-EPMC6402310 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature