AIE Multinuclear Ir(III) Complexes for Biocompatible Organic Nanoparticles with Highly Enhanced Photodynamic Performance.

ABSTRACT: The singlet oxygen (¹O₂) generation ability of a photosensitizer (PS) is pivotal for photodynamic therapy (PDT). Transition metal complexes are effective PSs, owing to their high ¹O₂ generation ability. However, non-negligible cellular toxicity, poor biocompatibility, and easy aggregation in water limit their biomedical applications. In this work, a series of red-emitting aggregation-induced emission (AIE) Ir(III) complexes containing different numbers of Ir centers (mono-, di-, and trinuclear) and the corresponding nanoparticles (NPs) AIE-NPs, are designed and synthesized. The increase of ¹O₂ generation ability is in line with the increasing number of Ir centers. Compared with the pure Ir(III) complexes, the corresponding N

SUBMITTER: Zhang L 

PROVIDER: S-EPMC6402395 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature