Stem cell-derived extracellular vesicles for myocardial infarction: a meta-analysis of controlled animal studies.

ABSTRACT: AimsStem cell-derived extracellular vesicles (EVs) have emerged as a promising therapy for myocardial infarction, but its effects remain incompletely understood. We aim to systematically review the efficacy of EVs on myocardial infarction in both small and large animals.MethodsOn April 5, 2018, we searched the PubMed, Embase and Web of Science databases using variations of "myocardial infarction" and "extracellular vesicle". Controlled studies about the treatment effects of stem cell-derived EVs in myocardial infarction animal model were included. Meta-regression analysis was used to reveal the factors affecting the EVs treatments.ResultsOf 1210 studies retrieved, 24 were eligible for meta-analysis. EVs injection was associated with the improvements of left ventricular

SUBMITTER: Yang L 

PROVIDER: S-EPMC6402509 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature