An immunoregulatory and tissue-residency program modulated by c-MAF in human T_H17 cells.

ABSTRACT: Different types of effector and memory T lymphocytes are induced and maintained in protective or pathological immune responses. Here we characterized two human CD4⁺ T_H17 helper cell subsets that, in the recently activated state, could be distinguished on the basis of their expression of the anti-inflammatory cytokine IL-10. IL-10⁺ T_H17 cells upregulated a variety of genes encoding immunoregulatory molecules, as well as genes whose expression is characteristic of tissue-resident T cells. In contrast, IL-10^- T_H17 cells maintained a pro-inflammatory gene-expression profile and upregulated the expression of homing receptors that guide recirculation from tissues to blood. Expression of the transcription factor c-MAF was selective

SUBMITTER: Aschenbrenner D 

PROVIDER: S-EPMC6402560 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature