The impact of amyloid-beta and tau on prospective cognitive decline in older individuals.

ABSTRACT:

Objectives

Amyloid-beta (Aβ) and tau pathologies are commonly observed among clinically normal older individuals at postmortem and can now be detected with in vivo neuroimaging. The association and interaction of these proteinopathies with prospective cognitive decline in normal aging and preclinical Alzheimer's disease (AD) remains to be fully elucidated.

Methods

One hundred thirty-seven older individuals (age = 76.3 ± 6.22 years) participating in the Harvard Aging Brain Study underwent Aβ (¹¹ C-Pittsburgh compound B) and tau (¹⁸ F-flortaucipir) positron emission tomography (PET) with prospective neuropsychological assessments following PET imaging (mean number of cognitive visits = 2.8 ± 1.1). Tau and Aβ PET measures were assessed in regions of intere

SUBMITTER: Sperling RA 

PROVIDER: S-EPMC6402593 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature