Mass Cytometry Analysis Reveals that Specific Intratumoral CD4⁺ T Cell Subsets Correlate with Patient Survival in Follicular Lymphoma.

ABSTRACT: Follicular lymphoma (FL) is an indolent B cell malignancy characterized by an extensive but poorly functional T cell infiltrate in the tumor microenvironment. Using mass cytometry, we identified at least 12 subsets of intratumoral CD4⁺ T cells, 3 of which were unique to FL biopsies versus control tissues. Of these subsets, the frequency of naive T cells correlated with improved patient survival. Although total PD-1⁺ T cell numbers were not associated with patient outcome, specific PD-1⁺ T cell subpopulations were associated with poor survival. Intratumoral T cells lacking CD27 and CD28 co-stimulatory receptor expression were enriched in FL and correlated with inferior patient outcomes. In vitro models revealed that CD70⁺ lymphoma cells played an

SUBMITTER: Yang ZZ 

PROVIDER: S-EPMC6402596 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature