Regulatory T cells mediate specific suppression by depleting peptide-MHC class II from dendritic cells.

ABSTRACT: Regulatory T cells (T_reg cells) can activate multiple suppressive mechanisms in vitro after activation via the T cell antigen receptor, resulting in antigen-independent suppression. However, it remains unclear whether similar pathways operate in vivo. Here we found that antigen-specific T_reg cells activated by dendritic cells (DCs) pulsed with two antigens suppressed conventional naive T cells (T_naive cells) specific for both cognate antigens and non-cognate antigens in vitro but suppressed only T_naive cells specific for cognate antigen in vivo. Antigen-specific T_reg cells formed strong interactions with DCs, resulting in selective inhibition of the binding of T_naive cells to cognate antigen yet allowing bystander T_naiv

SUBMITTER: Akkaya B 

PROVIDER: S-EPMC6402611 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature