The effect of a transient immune activation on subjective health perception in two placebo controlled randomised experiments.

ABSTRACT:

Background

Patient-reported outcomes predict mortality and play increasingly important roles in care, but factors that modify central measures such as health ratings have been little investigated. Building on designated immune-to-brain pathways, we aimed to determine how a short-term induced inflammation response impacts self-reported health status.

Methods

Lipopolysaccharide injections were used to provoke acute systemic inflammatory responses in healthy men and women and were compared to placebo in two double-blind randomized experiments. In Experiment 1, 8 individuals (mean 24 years; SD = 3.7) received lipopolysaccharide 0.8 ng/kg once and placebo once in a cross-over design, and in Experiment 2, 52 individuals received either lipopolysaccharide 0.6 ng/kg or placebo once

SUBMITTER: Andreasson A 

PROVIDER: S-EPMC6402640 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature