Assessing the role of transmission chains in the spread of HIV-1 among men who have sex with men in Quebec, Canada.

ABSTRACT:

Background

Phylogenetics has been used to investigate HIV transmission among men who have sex with men. This study compares several methodologies to elucidate the role of transmission chains in the dynamics of HIV spread in Quebec, Canada.

Methods

The Quebec Human Immunodeficiency Virus (HIV) genotyping program database now includes viral sequences from close to 4,000 HIV-positive individuals classified as Men who have Sex with Men (MSMs), collected between 1996 and early 2016. Assessment of chain expansion may depend on the partitioning scheme used, and so, we produce estimates from several methods: the conventional Bayesian and maximum likelihood-bootstrap methods, in combination with a variety of schemes for applying a maximum distance criterion, and two other algorithms,

SUBMITTER: Villandre L 

PROVIDER: S-EPMC6402664 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature