Characterization of mammalian Lipocalin UTRs in silico: Predictions for their role in post-transcriptional regulation.

ABSTRACT: The Lipocalin family is a group of homologous proteins characterized by its big array of functional capabilities. As extracellular proteins, they can bind small hydrophobic ligands through a well-conserved β-barrel folding. Lipocalins evolutionary history sprawls across many different taxa and shows great divergence even within chordates. This variability is also found in their heterogeneous tissue expression pattern. Although a handful of promoter regions have been previously described, studies on UTR regulatory roles in Lipocalin gene expression are scarce. Here we report a comprehensive bioinformatic analysis showing that complex post-transcriptional regulation exists in Lipocalin genes, as suggested by the presence of alternative UTRs with substantial sequence conservation in mammals,

SUBMITTER: Mejias A 

PROVIDER: S-EPMC6402760 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature