Platelet transfusions and mortality in necrotizing enterocolitis.

ABSTRACT:

Background

Prior studies have suggested an association between platelet transfusions (PTXs) and worse outcomes among infants with necrotizing enterocolitis (NEC), potentially mediated by proinflammatory factors released by platelets. However, the effects of storage on platelet proinflammatory factor release and the confounding role of illness severity on NEC outcomes have not been determined.

Study design and methods

First, neuropeptide Y (a potent splanchnic vasoconstrictor released by platelets) was measured by enzyme-linked immunosorbent assay in fresh frozen plasma and in the supernatant of leukoreduced apheresis-derived platelets at different times during storage. Next, we evaluated the relationship between PTX rates and death in a multicenter cohort of very-low-birth-w

SUBMITTER: Patel RM 

PROVIDER: S-EPMC6402966 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature