Defined Paraventricular Hypothalamic Populations Exhibit Differential Responses to Food Contingent on Caloric State.

ABSTRACT: Understanding the neural framework behind appetite control is fundamental to developing effective therapies to combat the obesity epidemic. The paraventricular hypothalamus (PVH) is critical for appetite regulation, yet, the real-time, physiological response properties of PVH neurons to nutrients are unknown. Using a combination of fiber photometry, electrophysiology, immunohistochemistry, and neural manipulation strategies, we determined the population dynamics of four molecularly delineated PVH subsets implicated in feeding behavior: glucagon-like peptide 1 receptor (PVH^Glp1r), melanocortin-4 receptor (PVH^Mc4r), oxytocin (PVH^Oxt), and corticotropin-releasing hormone (PVH^Crh). We identified both calorie- and state-dependent sustained activity in

SUBMITTER: Li C 

PROVIDER: S-EPMC6402975 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature