CPAP Adherence May Slow 1-Year Cognitive Decline in Older Adults with Mild Cognitive Impairment and Apnea.

ABSTRACT:

Background/objectives

Obstructive sleep apnea (OSA) has been linked to an increased risk for Alzheimer's disease (AD), but little prospective evidence exists on the effects of OSA treatment in preclinical AD. The objective was to determine if continuous positive airway pressure (CPAP) treatment adherence, controlling for baseline differences, predicts cognitive and everyday function after 1 year in older adults with mild cognitive impairment (MCI) and to determine effect sizes for a larger trial.

Design

Quasi-experimental pilot clinical trial with CPAP adherence defined as CPAP use 4 hours or more per night over 1 year.

Setting

Sleep and geriatric clinics and community.

Participants

Older adults, aged 55 to 89 years, with an apnea-hypopnea index of 10 or higher

SUBMITTER: Richards KC 

PROVIDER: S-EPMC6402995 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature