Comparing Vitamin D Supplementation Versus Placebo for Urgency Urinary Incontinence: A Pilot Study.

ABSTRACT:

Objectives

To estimate the efficacy of vitamin D supplementation to reduce urgency urinary incontinence (UUI) episodes.

Design

Pilot, two-arm, randomized trial conducted from 2013 to 2017. Interventions were 12 weeks of weekly oral 50,000 IU vitamin D3 or placebo.

Setting

Academic, university-based outpatient clinic.

Participants

Community-dwelling postmenopausal women, 50 years or older, with at least three UUI episodes on 7-day bladder diary and serum vitamin 25-hydroxyvitamin D (25[OH]D) of 30 ng/mL or less.

Measurements

The primary efficacy estimate was the percentage change in UUI episodes. Secondary estimates included changes in other lower urinary tract symptoms, along with exploratory subgroup analysis by race/ethnicity and obesity.

Results

SUBMITTER: Markland AD 

PROVIDER: S-EPMC6403014 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature