Multiparameter MRI Predictors of Long-Term Survival in Glioblastoma Multiforme.

ABSTRACT: Standard-of-care multiparameter magnetic resonance imaging (MRI) scans of the brain were used to objectively subdivide glioblastoma multiforme (GBM) tumors into regions that correspond to variations in blood flow, interstitial edema, and cellular density. We hypothesized that the distribution of these distinct tumor ecological "habitats" at the time of presentation will impact the course of the disease. We retrospectively analyzed initial MRI scans in 2 groups of patients diagnosed with GBM, a long-term survival group comprising subjects who survived >36 month postdiagnosis, and a short-term survival group comprising subjects who survived ≤19 month postdiagnosis. The single-institution discovery cohort contained 22 subjects in each group, while the multi-institution validation cohort conta

SUBMITTER: Stringfield O 

PROVIDER: S-EPMC6403044 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature