Probabilistic Category Learning and Striatal Functional Activation in Psychosis Risk.

ABSTRACT: BACKGROUND:Psychosis risk is associated with striatal dysfunction, including a previous behavioral study that found that psychosis risk is associated with impaired performance on a probabilistic category learning task (PCLT; ie, the Weather Prediction Task), a task strongly associated with striatal activation. The current study examined whether psychosis risk based on symptom levels was associated with both poor behavioral performance and task-related physiological dysfunction in specific regions of the striatum while performing the PCLT. METHODS:There were 2 groups of participants: psychosis risk (n = 21) who had both (a) extreme levels of self-reported psychotic-like beliefs and experiences and (b) interview-rated current attenuated psychotic symptoms (APS); and a comparison group (n = 2

SUBMITTER: Karcher NR 

PROVIDER: S-EPMC6403050 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature