Mismatch Negativity and Cortical Thickness in Patients With Schizophrenia and Bipolar Disorder.

ABSTRACT: INTRODUCTION:Mismatch negativity (MMN) is a measure of automatic neurophysiological brain processes for detecting unexpected sensory stimuli. This study investigated MMN reduction in patients with schizophrenia and bipolar disorder and examined whether cortical thickness is associated with MMN, for exploratory purposes. METHODS:Electroencephalograms were recorded in 38 patients with schizophrenia, 37 patients with bipolar disorder, and 32 healthy controls (HCs) performing a passive auditory oddball paradigm. All participants underwent T1 structural magnetic resonance imaging scanning to investigate the cortical thickness of MMN-generating regions. Average MMN amplitudes from the frontocentral electrodes were analyzed. RESULTS:Patients with schizophrenia and bipolar disorder exhibited signi

SUBMITTER: Kim S 

PROVIDER: S-EPMC6403065 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature