Peripheral Biomarkers in Schizophrenia: A Meta-Analysis of Microarray Gene Expression Datasets.

ABSTRACT:

Background

Schizophrenia is a severe psychiatric disorder with a complex pathophysiology. Given its prevalence, high risk of mortality, early onset, and high levels of disability, researchers have attempted to develop early detection strategies for facilitating timely pharmacological and/or nonpharmacological interventions. Here, we performed a meta-analysis of publicly available gene expression datasets in peripheral tissues in schizophrenia and healthy controls to detect consistent patterns of illness-associated gene expression. We also tested whether our earlier finding of a downregulation of NPTX2 expression in the brain of schizophrenia patients replicated in peripheral tissues.

Methods

We conducted a systematic search in the Gene Expression Omnibus repository (https://

SUBMITTER: Piras IS 

PROVIDER: S-EPMC6403089 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature