Clinical and genetic differences between pustular psoriasis subtypes.

ABSTRACT:

Background

The term pustular psoriasis indicates a group of severe skin disorders characterized by eruptions of neutrophil-filled pustules. The disease, which often manifests with concurrent psoriasis vulgaris, can have an acute systemic (generalized pustular psoriasis [GPP]) or chronic localized (palmoplantar pustulosis [PPP] and acrodermatitis continua of Hallopeau [ACH]) presentation. Although mutations have been uncovered in IL36RN and AP1S3, the rarity of the disease has hindered the study of genotype-phenotype correlations.

Objective

We sought to characterize the clinical and genetic features of pustular psoriasis through the analysis of an extended patient cohort.

Methods

We ascertained a data set of unprecedented size, including 863 unrelated patients (251 wit

SUBMITTER: Twelves S 

PROVIDER: S-EPMC6403101 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature