Clusterin in Alzheimer's Disease: Mechanisms, Genetics, and Lessons From Other Pathologies.

ABSTRACT: Clusterin (CLU) or APOJ is a multifunctional glycoprotein that has been implicated in several physiological and pathological states, including Alzheimer's disease (AD). With a prominent extracellular chaperone function, additional roles have been discussed for clusterin, including lipid transport and immune modulation, and it is involved in pathways common to several diseases such as cell death and survival, oxidative stress, and proteotoxic stress. Although clusterin is normally a secreted protein, it has also been found intracellularly under certain stress conditions. Multiple hypotheses have been proposed regarding the origin of intracellular clusterin, including specific biogenic processes leading to alternative transcripts and protein isoforms, but these lines of research are incomple

SUBMITTER: Foster EM 

PROVIDER: S-EPMC6403191 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature