Ultrafine particles and ozone perturb norepinephrine clearance rather than centrally generated sympathetic activity in humans.

ABSTRACT: Cardiovascular risk rapidly increased following exposure to air pollution. Changes in human autonomic regulation have been implicated based on epidemiological associations between exposure estimates and indirect autonomic nervous system measurements. We conducted a mechanistic study to test the hypothesis that, in healthy older individuals, well-defined experimental exposure to ultrafine carbon particles (UFP) increases sympathetic nervous system activity and more so with added ozone (O₃). Eighteen participants (age >50 years, 6 women) were exposed to filtered air (Air), UFP, and UFP + O₃ combination for 3 hours during intermittent bicycle ergometer training in a randomized, crossover, double-blind fashion. Two hours following exposure, respiration, electrocardiogram,

SUBMITTER: Heusser K 

PROVIDER: S-EPMC6403347 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature