Long term seizure freedom on perampanel in highly drug-resistant epilepsy caused by bilateral periventricular nodular heterotopia: A case report.

ABSTRACT: •NMDA-receptor subunit expression of NR2A and NR2B is downregulated in heterotopias.•Glutamatergic transmission in the hyperexcitability of nodular heterotopias is implicated.•Mechanisms in PVNH to establish etiology specific therapies are still to be defined.

SUBMITTER: Kiyose M 

PROVIDER: S-EPMC6403409 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature