Few Plasmodium falciparum merozoite ligand and erythrocyte receptor pairs show evidence of balancing selection.

ABSTRACT: Erythrocyte surface proteins have been identified as receptors of Plasmodium falciparum merozoite proteins. The ligand-receptor interactions enable the parasite to invade human erythrocytes, initiating the clinical symptoms of malaria. These interactions are likely to have had an evolutionary impact on the genes that encode the ligand and receptor proteins. We used sequence data from Kilifi, Kenya to detect departures from neutrality in a paired analysis of P. falciparum merozoite ligands and their erythrocyte receptor genes from the same population. We genotyped parasite and human DNA obtained from 93 individuals with severe malaria. We examined six merozoite ligands EBA175, EBL1, EBA140, MSP1, Rh4 and Rh5, and their corresponding erythrocyte receptors, glycophorin (Gyp) A, GypB, GypC, ba

SUBMITTER: Ochola-Oyier LI 

PROVIDER: S-EPMC6403450 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature