Costs and outcomes of Lynch syndrome screening in the Australian colorectal cancer population.

ABSTRACT:

Background and aim

Individuals with Lynch syndrome (LS) are at increased risk of LS-related cancers including colorectal cancer (CRC). CRC tumor screening for mismatch repair (MMR) deficiency is recommended in Australia to identify LS, although its cost-effectiveness has not been assessed. We aim to determine the cost-effectiveness of screening individuals with CRC for LS at different age-at-diagnosis thresholds.

Methods

We developed a decision analysis model to estimate yield and costs of LS screening. Age-specific probabilities of LS diagnosis were based on Australian data. Two CRC tumor screening pathways were assessed (MMR immunohistochemistry followed by MLH1 methylation (MLH1-Pathway) or BRAF V600E testing (BRAF-Pathway) if MLH1 expression was lost) for four age-at-dia

SUBMITTER: Cenin DR 

PROVIDER: S-EPMC6403824 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature