Thermoadaptive Supramolecular α-Cyclodextrin Crystallization-Based Hydrogels via Double Hydrophilic Block Copolymer Templating.

ABSTRACT: Supramolecular hydrogels play a prominent role in contemporary research of hydrophilic polymers. Especially, hydrogels based on α-cyclodextrin/poly(ethylene glycol) (α-CD/PEG) complexation and crystal formation are studied frequently. Here, the effect of double hydrophilic block copolymers (DHBCs) on α-CD/PEG hydrogel properties is investigated. Therefore, a novel DHBC, namely poly(N-vinylpyrrolidone)-b-poly(oligo ethylene glycol methacrylate) (PVP-b-POEGMA), was synthesized via a combination of reversible deactivation radical polymerization and modular conjugation methods. In the next step, hydrogel formation was studied after α-CD addition. Interestingly, DHBC-based hydrogels showed a significant response to thermal history. Heating of the gels to different temperatures led to different

SUBMITTER: Li T 

PROVIDER: S-EPMC6404023 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature