Sirt1 Antisense Long Noncoding RNA Promotes Cardiomyocyte Proliferation by Enhancing the Stability of Sirt1.

ABSTRACT: Background Antisense long noncoding RNAs (lnc RNA s) are single-stranded RNA s that overlapped gene-coding regions on the opposite DNA strand and play as critical regulators in cardiovascular diseases. The high conservation and stability may be good advantages for antisense lnc RNA s. However, the roles of antisense lnc RNA s in cardiomyocyte proliferation and cardiac regeneration are still unknown. Methods and Results In this study, we found that Silent information regulator factor 2 related enzyme 1 (Sirt1) antisense lnc RNA expression was significantly increased during heart development. By gain and loss function of Sirt1 antisense lnc RNA using adenovirus and locked nucleic acid, respectively, we demonstrated that Sirt1 antisense lnc RNA promoted cardiomyocyte proliferation in vitro an

SUBMITTER: Li B 

PROVIDER: S-EPMC6404207 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature