Change of Kidney Function Is Associated With All-Cause Mortality and Cardiovascular Diseases: Results From the Kailuan Study.

ABSTRACT: Background Current evaluation about the relationship of sequential change in estimated glomerular filtration rate ( eGFR ) and clinical outcomes are still inconsistent. We aimed to investigate the association between the change in kidney function over time and the risk of all-cause mortality and cardiovascular disease. Methods and Results This prospective cohort including 37 691 participants aged ≥45 years used data from the Kailuan Health Registry. The relationship of the annual percentage and absolute change in eGFR and outcomes were analyzed with Cox proportional regression. The participants were stratified according to the quintiles distribution of the percentage annual change in eGFR (Q1-Q5). After adjusting for baseline covariates including initial eGFR , participants with annual eGF

SUBMITTER: Guo Y 

PROVIDER: S-EPMC6404220 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature