Association of Oral Anticoagulants and Proton Pump Inhibitor Cotherapy With Hospitalization for Upper Gastrointestinal Tract Bleeding.

ABSTRACT:

Importance

Anticoagulant choice and proton pump inhibitor (PPI) cotherapy could affect the risk of upper gastrointestinal tract bleeding, a frequent and potentially serious complication of oral anticoagulant treatment.

Objectives

To compare the incidence of hospitalization for upper gastrointestinal tract bleeding in patients using individual anticoagulants with and without PPI cotherapy, and to determine variation according to underlying gastrointestinal bleeding risk.

Design, setting, and participants

Retrospective cohort study in Medicare beneficiaries between January 1, 2011, and September 30, 2015.

Exposures

Apixaban, dabigatran, rivaroxaban, or warfarin with or without PPI cotherapy.

Main outcomes and measures

Hospitalizations for upper gastrointes

SUBMITTER: Ray WA 

PROVIDER: S-EPMC6404233 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature