Sex and Mitonuclear Adaptation in Experimental Caenorhabditis elegans Populations.

ABSTRACT: To reveal phenotypic and functional genomic patterns of mitonuclear adaptation, a laboratory adaptation study with Caenorhabditis elegans nematodes was conducted in which independently evolving lines were initiated from a low-fitness mitochondrial electron transport chain (ETC) mutant, gas-1 Following 60 generations of evolution in large population sizes with competition for food resources, two distinct classes of lines representing different degrees of adaptive response emerged: a low-fitness class that exhibited minimal or no improvement compared to the gas-1 mutant ancestor, and a high-fitness class containing lines that exhibited partial recovery of wild-type fitness. Many lines that achieved higher reproductive and competitive fitness levels were also noted to evo

SUBMITTER: Wernick RI 

PROVIDER: S-EPMC6404257 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature