Spore Germination Requires Ferrichrome Biosynthesis and the Siderophore Transporter Str1 in Schizosaccharomyces pombe.

ABSTRACT: Spore germination is a process whereby spores exit dormancy to become competent for mitotic cell division. In Schizosaccharomyces pombe, one critical step of germination is the formation of a germ tube that hatches out the spore wall in a stage called outgrowth. Here, we show that iron deficiency blocks the outgrowth of germinating spores. The siderophore synthetase Sib1 and the ornithine N⁵-oxygenase Sib2 participate in ferrichrome biosynthesis, whereas Str1 functions as a ferrichrome transporter. Expression profiles of sib1⁺ , sib2⁺ , and str1⁺ transcripts reveal that they are induced shortly after induction of germination and their expression remains upregulated throughout the germination program under low-iron cond

SUBMITTER: Plante S 

PROVIDER: S-EPMC6404258 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature