Regenerative cell therapy for pulmonary arterial hypertension in animal models: a systematic review.

ABSTRACT:

Background

Pulmonary arterial hypertension (PAH) is a rare disease characterized by widespread loss of the pulmonary microcirculation and elevated pulmonary arterial pressures leading to pathological right ventricular remodeling and ultimately right heart failure. Regenerative cell therapies could potentially restore the effective lung microcirculation and provide a curative therapy for PAH. The objective of this systematic review was to compare the efficacy of regenerative cell therapies in preclinical models of PAH.

Methods

A systematic search strategy was developed and executed. We included preclinical animal studies using regenerative cell therapy in experimental models of PAH. Primary outcomes were right ventricular systolic pressure (RVSP) and mean pulmonary arterial p

SUBMITTER: Suen CM 

PROVIDER: S-EPMC6404277 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature