Separation of breast cancer and organ microenvironment transcriptomes in metastases.

ABSTRACT:

Background

The seed and soil hypothesis was proposed over a century ago to describe why cancer cells (seeds) grow in certain organs (soil). Since then, the genetic properties that define the cancer cells have been heavily investigated; however, genomic mediators within the organ microenvironment that mediate successful metastatic growth are less understood. These studies sought to identify cancer- and organ-specific genomic programs that mediate metastasis.

Methods

In these studies, a set of 14 human breast cancer patient-derived xenograft (PDX) metastasis models was developed and then tested for metastatic tropism with two approaches: spontaneous metastases from mammary tumors and intravenous injection of PDX cells. The transcriptomes of the cancer cells when growing as tum

SUBMITTER: Alzubi MA 

PROVIDER: S-EPMC6404325 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature