Digoxin and Platelet Activation in Patients With Atrial Fibrillation: In Vivo and In Vitro Study.

ABSTRACT: Background Digoxin use was shown to be associated with an increased risk of cardiovascular events in atrial fibrillation ( AF ). We hypothesized that digoxin may affect cardiovascular risk by increasing platelet activation. Methods and Results Post hoc analysis of a prospective study of anticoagulated patients with AF . Patients were divided into 2 groups balanced for age, sex, and cardiovascular risk factors: digoxin users (n=132) and nonusers (n=388). Urinary excretion of 11-dehydro-thromboxane B₂ (TxB₂), a marker of platelet activation, and serum digoxin concentration ( SDC ) were measured. In vitro experiments were performed on platelets from healthy subjects and AF patients, which were incubated with scalar doses of digoxin (0.6-2.4 ng/mL) with or without prestim

SUBMITTER: Pastori D 

PROVIDER: S-EPMC6404445 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature