Serum magnesium and calcium levels in relation to ischemic stroke: Mendelian randomization study.

ABSTRACT:

Objective

To determine whether serum magnesium and calcium concentrations are causally associated with ischemic stroke or any of its subtypes using the mendelian randomization approach.

Methods

Analyses were conducted using summary statistics data for 13 single-nucleotide polymorphisms robustly associated with serum magnesium (n = 6) or serum calcium (n = 7) concentrations. The corresponding data for ischemic stroke were obtained from the MEGASTROKE consortium (34,217 cases and 404,630 noncases).

Results

In standard mendelian randomization analysis, the odds ratios for each 0.1 mmol/L (about 1 SD) increase in genetically predicted serum magnesium concentrations were 0.78 (95% confidence interval [CI] 0.69-0.89; p = 1.3 × 10^-4) for all ischemic stroke

SUBMITTER: Larsson SC 

PROVIDER: S-EPMC6404465 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature