Histopathology of diffusion imaging abnormalities in cerebral amyloid angiopathy.

ABSTRACT:

Objective

We sought to determine the underlying mechanism for altered white matter diffusion tensor imaging (DTI) measures at the histopathologic level in patients with cerebral amyloid angiopathy (CAA).

Methods

Formalin-fixed intact hemispheres from 9 CAA cases and 2 elderly controls were scanned at 3-tesla MRI, including a diffusion-weighted sequence. DTI measures (i.e., fractional anisotropy [FA] and mean diffusivity [MD]) and histopathology measures were obtained from 2 tracts: the anterior thalamic radiation and inferior longitudinal fasciculus.

Results

FA was reduced in both tracts and MD was increased in cases with CAA compared to controls. Regional FA was significantly correlated with tissue rarefaction, myelin density, axonal density, and white matter microin

SUBMITTER: van Veluw SJ 

PROVIDER: S-EPMC6404469 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature